Dr. Andrey Grigoriev, Professor of Biology will present “New Fragments of Old Molecules.”

 

Date: Monday, April 15, 2019
Doors open at 11 a.m., lecture starts at 11:20 a.m.
Location: Multipurpose Room – Campus Center

Registration is required.

Register here

 

Andrey Grigoriev

About Dr. Andrey Grigoriev

Dr. Andrey Grigoriev, Professor of Biology, is the founding director of the Center for Computational and Integrative Biology and its graduate program at Rutgers University–Camden. He came to Rutgers–Camden in 2010 after a career as the scientific director at Bioinformatics.

Dr. Grigoriev earned his Bachelor of Science degree and Master of Science degree in physics from the Moscow Engineering Physics Institute in 1986. After the completion of these degrees, Dr. Grigoriev developed computer games, ultimately winning four gold medals for programming logical games at the Computer Olympiads from 1989-1991. He also published ten books on C programming from 1988-1991.

From 1992-1995, Dr. Grigoriev conducted research developing algorithms and software for physical map construction at the Imperial Cancer Research Fund in London. He then went on to obtain his doctorate in molecular biology from the Institute of Genetics and Selection of Industrial Microorganisms in Moscow in 1995. He then served as a scientist at the Max-Planck Institute for Molecular Genetics in Berlin before becoming a group leader at GPC Biotech in Martinsried, Germany.

During his time at Rutgers–Camden, Dr. Grigoriev’s work has been supported by grants from the National Science Foundation, National Institutes of Health, New Jersey Health Foundation, and internal Rutgers University grants, such as the Provost’s Fund for Research. In his lab, Dr. Grigoriev combines the fields of biology and computer science and pushes the research boundaries toward new evolutionary, health-related and societal paradigms.

About “New Fragments of Old Molecules”

This public lecture will describe novel ground-breaking research directions at an intersection of computational and biological sciences, focused on inferring the function of very new “players” detected in living cells. Transfer and ribosomal RNAs have very old and well-defined textbook roles as key players in protein translation. Fragments of these molecules were traditionally considered to be “noise”, or results of random breakage. As it turns out, Nature continues to utilize seemingly unneeded things – nothing goes to waste, including even the smallest fragments of RNA molecules.

Recently, significant novel findings, have revealed completely unexpected new functionality of such fragments. They are now recognized to have a likely regulatory function and added to the repertoire of so called small RNAs, whose function challenges our current understanding of evolution and life.

These small fragments seem to affect offspring’s health based on fathers’ diet in a complex way. It has been shown that such lifestyle information is conveyed by loading fragments into sperm during its maturation for regulating future embryonic development based on high fat or high protein diet of their fathers. These RNAs may be the carriers of information from the lesser-known pangenesis hypothesis of Darwin.

Serious diseases appear to be affected by the action of small RNAs as well, including the deadliest cancers. Artificial small RNA analogs are entering clinical trials, to provide revolutionary new drugs and offer cure for previously untreatable human conditions.

Small RNAs enable novel ways of information transfer, including effects across boundaries of species and kingdoms of life. Development of bee larvae into queens or workers seem to be regulated by plants and driven by signals passed to insects via RNAs present in bee’s food (pollen or royal jelly). Diseases of agricultural crops are accelerated by small RNAs produced by their pathogens.

Thus our work on small RNA goes beyond the traditional specialized realm of biological studies and pushes the research boundaries towards new evolutionary, health-related and societal paradigms.